ABSTRACT
Objectives This study aims to investigate the impact of various demographic, environmental, and topographical factors on COVID-19 mortality rates in different geographical provinces of Iran.Methods The research utilized data from DATASUS (Ministry of Health), International Classification of Diseases (ICD-10), WorldClimV1, Sentinel-5P TROPOMI-based datasets, Open Street Map (OSM), and the Shuttle Radar Topography Mission satellite (SRTM) to gather mortality, demographic, environmental, and topographical data, evaluating them by sex, age group, and province. The analysis employed Geographic Information Systems methodology and logistic regression.Results Higher mortality rates were observed in the central and southern regions, with West Azerbaijan and Sistan-Baluchestan provinces showing elevated rates compared to their population sizes. Additionally, South Khorasan, Sistan-Baluchestan, Semnan, Bushehr, and Ilam provinces exhibited higher mortality ratios relative to mean temperature. The central and southern provinces displayed a higher ratio of air pollution concerning Covid-19 mortality, notably around Uremia Lake, showing a significant correlation. Logistic regression analysis revealed positive correlations of NO2 and O3 with Covid-19 mortality, while CO2 and SO2 showed negative correlations. Furthermore, population, population density, and area emerged as the most influential factors affecting the Covid-19 mortality rate.Conclusions The findings of this study offer valuable insights for policymakers and public health officials to develop targeted interventions for reducing the virus's impact in high-risk areas and enhancing healthcare resources and infrastructure in urban settings.